11/5/2023 0 Comments Pcn allergy cross reactivityAvoid one where there is a history of allergy to the other. Ceftazidime and aztreonam have the same side chain.These cephalosporins all have the same or similar side chains. Ceftriaxone allergy – avoid cefotaxime, cefepime and cefuroxime.Cefalexin and cefaclor have a similar side chain to amoxicillin: Avoid cefalexin or cefaclor if the patient has a history of serious amoxicillin or ampicillin allergy.Cefazolin has no common side-chains with other beta-lactam antibiotics, so can often be tolerated in patients with a penicillin or a cephalosporin allergy.Similar - Cefepime, Ceftriaxone, Cefotaxime, Ceftazidime.Similar - Ampicillin, Cefaclor, Cefalexin.1Īntibiotics with shared structural similarities, such as those with the same or similar R1-group side-chains are more likely to cross-react: An estimated 1-2% of patients with a penicillin allergy react to cephalosporins. The prevalence of cross-reactivity between beta-lactams is lower than originally thought. Piperacillin with tazobactam - Tazopip, PiperTaz, Tazocin, Piptaz Procaine benzylpenicillin CilicaineĬross-reactivity between beta-lactamclassesĪ history of penicillin allergy should not rule out the use of cephalosporins.Phenoxymethylpenicillin (Penicillin V) - Aspecillin, Cilicaine VK, Cilicaine V, Cilopen.Flucloxacillin - Flubiclox, Flucil, Flopen, Flucil, Staphylex.Benzathine benzylpenicillin - Bicillin-LA.Benzylpenicillin (Penicillin G) - BenPen.Ampicillin - Agpen, Alphacyn, Ampicyn, Austrapen, Ibimicyn, Penamp. ![]()
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