11/6/2023 0 Comments Lesiones en el cerebroIt closely mimics metastatic epithelioid carcinoma or amelanotic metastatic melanoma histologically. This glioblastoma variant can cause diagnostic confusion on several levels, including on preoperative imaging evaluation and on histopathologic examination. It has not yet been formally codified in the World Health Organization (WHO) Classification of Tumours of the Central Nervous System 9. Metástasis.Įpithelioid glioblastoma is a rare morphological subtype of glioblastoma 5,8,15,16. El intento de resección total se recomienda cuando éste sea viable para obtener un diagnóstico definitivo así como para mejorar la supervivencia libre de enfermedad en pacientes cuya presentación incluya lesiones múltiples que puedan dirigir a un tratamiento inadecuado. Este diagnóstico debe ser incluido en el diferencial de pacientes con lesiones multifocales. Los autores describen aquí el primer caso de glioblastoma epiteloide multifocal con apariencia de metástasis secundaria. El glioblastoma epiteloide es uno de los subtipos morfológicos mas raros de glioblastoma. Mediante dos craneotomías independientes, ambas lesiones se resecaron in toto con buen resultado post-quirúrgico.Ĭonclusión. Dos lesiones sospechosas de metástasis fueron identificadas por resonancia magnética. Varón de 67 años con historia previa de micosis fungoide, una forma común de linfoma cutáneo e células T, cuyos síntomas fueron pérdida de memoria y alteraciones del campo visual periférico. Presentamos el primer caso de glioblastoma multifocal epiteloide imitando metástasis cerebral. Todos los casos reportados de esta variante inusual de glioblastoma han sido lesiones solitarias. El glioblastoma epiteloide es un subtipo morfológico poco común del glioblastoma que puede imitar al carcinoma o melanoma metastásico histológicamente. An attempt at gross total resection is recommended when anatomically feasible for definitive histopathological diagnosis and to improve progression free survival of patients who present with similarly ambiguous and potentially misleading multiple lesions. Multifocal epithelioid glioblastoma should be included in the differential diagnosis of patients who present with multiple discrete brain lesions. Here we describe the first case to our knowledge of multifocal epithelioid glioblastoma that convincingly mimicked a secondary metastatic process. Epithelioid glioblastoma is one of the rarest morphologic subtypes of glioblastoma. The patient underwent two separate craniotomies both lesions were successfully resected in toto with an excellent post-surgical outcome.Ĭonclusion. Two discrete brain lesions highly suspicious for metastases were identified by magnetic resonance imaging (MRI). A 67-year-old man with a prior history of mycosis fungoides, a common form of cutaneous T-cell lymphoma, presented with memory loss and impaired peripheral vision. We report here the first case to our knowledge of multifocal epithelioid glioblastoma mimicking cerebral metastasis.Ĭlinical presentation. All previous case reports of this unusual glioblastoma variant have been solitary lesions. Epithelioid glioblastoma is a rare morphologic subtype of glioblastoma that closely mimics metastatic carcinoma or metastatic melanoma histologically. *Division of Neurosurgery, The University of Texas Medical Branch, Galveston. Glioblastoma epiteloide multifocal simulando metástasis cerebrales. Multifocal epithelioid glioblastoma mimicking cerebral metastasis: case report
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